IGG MONOCLONAL-ANTIBODIES THAT INHIBIT OSTEOINDUCTIVITY OF HUMAN BONEMATRIX-DERIVED PROTEINS (HBMP NCP)/

Authors
KUBLER N REUTHER J KIRCHNER T PFAFF M MULLERHERMELINK HK ALBERT R SEBALD W
Citation
N. Kubler et al., IGG MONOCLONAL-ANTIBODIES THAT INHIBIT OSTEOINDUCTIVITY OF HUMAN BONEMATRIX-DERIVED PROTEINS (HBMP NCP)/, International journal of oral and maxillofacial surgery, 23(6), 1994, pp. 420-422
Citations number
4
Categorie Soggetti
Dentistry,Oral Surgery & Medicine
Journal title
International journal of oral and maxillofacial surgery → ACNP
ISSN journal
09015027
Volume
23
Issue
6
Year of publication
1994
Part
2
Pages
420 - 422
Database
ISI
SICI code
0901-5027(1994)23:6<420:IMTIOO>2.0.ZU;2-3
Abstract
Monoclonal hBMP/NCP (human bone morphogenetic protein and associated n oncollagenous proteins) antibodies of the IgG class were produced. In vitro, 12 of 19 hBMP/NCP antibodies showed functional inhibition of hB MP/NCP-induced chondroneogenesis in a neonatal muscle tissue assay. In ducing factors were characterized by their inhibiting antibodies with immunoblotting. Several peptide factors seem to be involved in the cas cade of induced chondro- and osteogenesis.