Objective: To show that intrauterine anesthesia is a reliable method f
or reducing pain associated with endocavitary procedures. Design: A pr
ospective, randomized, double-blind study. Setting: The Department of
Obstetrics and Gynecology, Tor Vergata University of Rome, Rome, Italy
. Patients: Forty-five patients undergoing diagnostic hysteroscopy (n
= 27) or hysteroscopy and endometrial biopsy (n = 18). Interventions:
Five milliliters of 2% mepivacaine or saline solution were injected tr
anscervically into the uterine cavity before performing the procedures
.Main Outcome Measures: Evaluation of pain reduction on a visual analo
gue scale. Results: Pain expectation and pain reported were reduced du
ring and after the procedures. Conclusion: Topical anesthesia effectiv
ely reduces pain during hysteroscopy and endometrial biopsy.