ATTENUATED LIVE CHOLERA VACCINE STRAIN CVD-103-HGR ELICITS SIGNIFICANTLY HIGHER SERUM VIBRIOCIDAL ANTIBODY-TITERS IN PERSONS OF BLOOD-GROUP-O

Authors
LAGOS R AVENDANO A PRADO V HORWITZ I WASSERMAN S LOSONSKY G CRYZ S KAPER JB LEVINE MM
Citation
R. Lagos et al., ATTENUATED LIVE CHOLERA VACCINE STRAIN CVD-103-HGR ELICITS SIGNIFICANTLY HIGHER SERUM VIBRIOCIDAL ANTIBODY-TITERS IN PERSONS OF BLOOD-GROUP-O, Infection and immunity, 63(2), 1995, pp. 707-709
Citations number
31
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
63
Issue
2
Year of publication
1995
Pages
707 - 709
Database
ISI
SICI code
0019-9567(1995)63:2<707:ALCVSC>2.0.ZU;2-J
Abstract
Persons of blood group O are at increased risk of developing cholera g ravis. In a randomized, placebo-controlled, double-blind safety-immuno genicity trial of live oral cholera vaccine CVD 103-HgR in 5- to 9-yea r-old Chilean children, vibriocidal antibody seroconversion (74% overa ll) did not differ by blood group. However, the reciprocal geometric m ean titer (GMT) in blood group O vaccinees (GMT = 486) was higher than that in non-O vaccines (GMT = 179) (P < 0.02).