The authors report the results of 782 microvascular decompression proc
edures for hemifacial spasm in 703 patients (705 sides), with follow-u
p study from 1 to 20 years (mean 8 years). Of 648 patients who had not
undergone prior intracranial procedures for hemifacial spasm, 65% wer
e women; their mean age was 52 years, and the mean preoperative durati
on of symptoms was 7 years. The onset of symptoms was typical in 92% a
nd atypical in 8%. An additional 57 patients who had undergone prior m
icrovascular decompression elsewhere were analyzed as a separate group
. Patients were followed prospectively with annual questionnaires. Kap
lan-Meier methods showed that among patients without prior microvascul
ar decompression elsewhere, 84% had excellent results and 7% had parti
al success 10 years postoperatively. Subgroup analyses (Cox proportion
al hazards model) showed that men had better results than women, and p
atients with typical onset of symptoms had better results than those w
ith atypical onset. Nearly all failures occurred within 24 months of o
peration; 9% of patients underwent reoperation for recurrent symptoms.
Second microvascular decompression procedures were less successful, w
hether the first procedure was performed at Presbyterian-University Ho
spital or elsewhere, unless the procedure was performed within 30 days
after the first microvascular decompression. Patient age, side and pr
eoperative duration of symptoms, history of Hell's palsy, preoperative
presence of facial weakness or synkinesis, and implant material used
had no influence on postoperative results. Complications after the fir
st microvascular decompression for hemifacial spasm included ipsilater
al deaf ear in 2.6% and ipsilateral permanent, severe facial weakness
in 0.9% of patients. Complications were more frequent in reoperated pa
tients. In all, one operative death (0.1%) and two brainstem infarctio
ns (0.3%) occurred. Microvascular decompression is a safe and definiti
ve treatment for hemifacial spasm with proven long-term efficacy.