INTELLIGENT AUTOMATED CORRECTION OF BASEPLANE AND SYSTEMATIC NOISE IN2-DIMENSIONAL NMR-SPECTRA

A computer program useful for 2D NMR data is described that provides a utomatic two-dimensional baseplane correction and subsequent tl and fl ridge suppression. The algorithm per forms combined correction of smo oth baseplane distortions and sharp ridges in 2D NMR spectra through f ive steps: (1) identification of resonance peaks and ridges, (2) extra ction of initial, putative global baseplane, (3) window filtering of t he corresponding time domain, (4) construction of a 2D spectrum free o f baseplane distortion, and (5) suppression of ridges, The optimal par ameters for baseplane and ridge correction are automatically decided b y the program, yielding a greatly improved spectrum, together with mor e accurate spectral information. (C) 1994 Academic Press, Inc.