RABBIT AND FERRET PARIETAL-CELL INHIBITION BY HELICOBACTER SPECIES

We tested sonicates of Helicobacter pylori, H. mustelae, and H. felis for inhibition of acid secretion in rabbit and ferret isolated gastric glands. Three H. pylori strains, two of three H. mustelae strains, an d two H. felis strains significantly inhibited acid secretion in rabbi t cells by 95.2-93.3%, 55.9% and 96.4%, and 83.4-96%, respectively. Al l Helicobacter strains examined inhibited acid secretion by ferret cel ls by 65.3-76.8%, 89.1-97.6%, and 85.8-92.8%. H. pylori inhibited acid secretion after stimulation with histamine and isobutylmethylxanthine or with 8-bromo-cyclic adenosine monophosphate (P < 0.05 for all test s). These findings demonstrate that acid inhibition is a property comm on to the three Helicobacter species tested. It occurs independently o f the mammalian origin of the parietal cell, and it does not involve b lockade of histamine-2 receptors.