PAROMOMYCIN-ASSOCIATED PANCREATITIS HIV-RELATED CRYPTOSPORIDIOSIS

OBJECTIVE: TO report a case of pancreatitis related to paromomycin adm inistration. CASE SUMMARY: A 39-year-old man with AIDS developed pancr eatitis concurrent with successful treatment of intestinal cryptospori diosis with paromomycin. The hyperamylasemia resolved with discontinua tion of the agent and recurred when paromomycin treatment was reinstit uted. DISCUSSION: TO OUT knowledge, this is the first reported case of pancreatitis believed to be induced by paromomycin. Although pancreat itis in HIV-infected patients has multiple causes, the nature of this case suggests the involvement of paromomycin. The mechanism of action is unclear. CONCLUSIONS: Pancreatitis should be considered in the diff erential diagnosis of abdominal pain in patients who are treated with paromomycin.