ACUTE INVASIVE RHINOCEREBRAL ZYGOMYCOSIS IN AN OTHERWISE HEALTHY PATIENT - CASE-REPORT AND REVIEW

A previously healthy 19-year-old man developed rapidly progressive inv asive rhinocerebral zygomycosis due to Apophysomyces elegans. He requi red extensive surgery and prolonged treatment with high-dose iv amphot ericin B for cure. This is only the third reported case of acute invas ive rhinocerebral zygomycosis in an otherwise healthy patient and the first reported case of infection due to A, elegans in any patient, We review the literature and clinical spectrum of rhinocerebral zygomycos is in otherwise healthy patients and discuss the recently recognized a ssociation between A. elegans and zygomycosis in immunocompetent patie nts.