The significance of candiduria ranges from simple procurement-related
contamination to disseminated candidiasis, Ensuring that a valid urine
specimen is collected and carefully assessing patients for risk facto
rs predisposing to disseminated candidiasis permit the stratification
of cases into three clinical categories: (1) asymptomatic candiduria i
n a previously healthy patient; (2) candiduria in a high-risk patient
in whom disseminated candidiasis is unlikely; and (3) candiduria in a
high-risk patient with a potential for disseminated candidiasis, Strat
egies for management are tailored to the individual patient. Appropria
te management of anatomic genitourinary abnormalities and removal of b
ladder catheters may result in the resolution of candiduria, although
some patients require systemic antifungal therapy. All patients with c
andiduria should be evaluated for evidence of deep-seated tissue infec
tion or candidemia before therapy is instituted, Fluconazole appears t
o be a safe and effective agent for the management of candidal urinary
tract infection, Both its safety and its ease of administration make
it superior to amphotericin B for this purpose.