Hs. Hyun et al., LOPERAMIDE DOES NOT AFFECT THE PROSTAGLANDIN E(2) (PGE(2))-INDUCED ANTI-ABSORPTIVE EFFECT ON GLUCOSE IN THE SMALL-INTESTINAL LOOP OF SHEEP, Journal of animal physiology and animal nutrition, 76(2-3), 1996, pp. 80-89
This study was designed to clarify whether the anti-absorptive effects
of PGE(2) on glucose were associated with hypersecretion induced by P
GE(2). Loperamide, which is known to prevent PGE(2)-induced secretion
in the intestine and to have an antidiarrhoeal action, was used for bl
ocking the PGE(2)-induced secretory response. Loperamide significantly
increased the basal net absorption of water, sodium, and chloride, an
d decreased those secretory responses to PGE(2). However, loperamide d
id not change the basal glucose absorption and did not improve the inh
ibition of glucose absorption induced by PGE(2). These results suggest
that PGE(2) can inhibit glucose absorption by a different mechanism f
rom that which produces the secretory effect. In conclusion, these res
ults indicate that loperamide induces the antisecretory effect by an i
ncrease in sodium and chloride absorption in the small intestine of sh
eep, bur does not affect the anti-absorptive effect of PGE(2) on gluco
se.