POLYMORPHISM OF THE GENE ENCODING A HUMAN MINIMAL POTASSIUM-ION CHANNEL (MINK)

A gene (minK) that encodes a minimal potassium channel has been cloned recently. We describe in this paper a human minK sequence which diffe rs from the original sequence with a single A-->G at position 112; Thi s resulted in a change from a Ser codon (AGT) to a Gly codon (GGT) and created a new MspAI restriction site. Of the 32 alleles from 16 subje cts studied, 25 had this newly discovered sequence and 7 had the previ ously described sequence.