COMPARISON OF SIMULATED AND IN-VIVO PLASMA-LEVELS OF CILASTATIN FOLLOWING INTRAVENOUS IN-LINE DRUG ADMINISTRATION

The primary objective of this work was to establish a method to simula te the plasma levels of cilastatin, a model drug, following an intrave nous in-line delivery scheme. In-vivo data in dogs obtained from this work were used to demonstrate the validity of the proposed approach. T he in-line drug delivery system consists of a drug containing device w hich is placed between a large volume parenteral and a patient. Numero us advantages have been identified for this automatic in-line reconsti tution delivery system. The numerical convolution integral algorithm w as used in this work to perform plasma profile simulation. The results indicated that the simulated cilastatin plasma profile following in-l ine delivery closely agreed with the in-vivo data.