TAU-IMMUNOREACTIVITY ASSOCIATED WITH ALUMINUM MALTOLATE-INDUCED NEUROFIBRILLARY DEGENERATION IN RABBITS

Authors
SAVORY J HUANG Y HERMAN MM REYES MR WILLS MR
Citation
J. Savory et al., TAU-IMMUNOREACTIVITY ASSOCIATED WITH ALUMINUM MALTOLATE-INDUCED NEUROFIBRILLARY DEGENERATION IN RABBITS, Brain research, 669(2), 1995, pp. 325-329
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
669
Issue
2
Year of publication
1995
Pages
325 - 329
Database
ISI
SICI code
0006-8993(1995)669:2<325:TAWAMN>2.0.ZU;2-#
Abstract
Intracisternal administration of aluminum maltolate to rabbits produce s a marked argyrophilic neurofibrillary degeneration (NFD) which is al so immunoreactive for both phosphorylated and non-phosphorylated micro tubule associated protein tau. Using tissue fixation in PBF, the monoc lonal antibodies Tau-2 and AT8 stain the NFD. Dephosphorylation marked ly reduces the positivity of AT8. Using PLP-fixed tissue, monoclonal a ntibody Tau-1 also immunostains aluminum-induced NFD.