TYPE-II DIABETES AFTER COMBINED KIDNEY AND PANCREAS TRANSPLANTATION FOR TYPE-I DIABETES-MELLITUS AND END-STAGE RENAL-DISEASE

We report a case of a patient who developed type II diabetes after rec eiving a successful combined kidney and pancreas transplant for type I diabetes and end-stage renal disease. This patient underwent a combin ed kidney and pancreas transplant and had no evidence of rejection wit h good function following the transplant for nine months. The patient developed significant post-transplant obesity with her transplant weig ht of 80 kg rising to 109 kg. At this level of obesity, the patient de veloped fasting hyperglycemia of 180 mg/dl with no change in her renal function or her pancreas exocrine function. She developed hyperinsuli nemia to this fasting hyperglycemia. The clinical course of this patie nt demonstrates that rapid weight transplantation can result in type I I diabetes.