EFFECT OF PHENAZONE (ANTIPYRINE) ON THE PROSTANOID FORMATION IN HUMANUMBILICAL ARTERIES PERFUSED IN-VITRO

Authors
HAUGEN G STRAYPEDERSEN S BJORO K
Citation
G. Haugen et al., EFFECT OF PHENAZONE (ANTIPYRINE) ON THE PROSTANOID FORMATION IN HUMANUMBILICAL ARTERIES PERFUSED IN-VITRO, Gynecologic and obstetric investigation, 39(1), 1995, pp. 8-10
Citations number
9
Categorie Soggetti
Obsetric & Gynecology
Journal title
Gynecologic and obstetric investigation → ACNP
ISSN journal
03787346
Volume
39
Issue
1
Year of publication
1995
Pages
8 - 10
Database
ISI
SICI code
0378-7346(1995)39:1<8:EOP(OT>2.0.ZU;2-I
Abstract
The influence of phenazone on the production of prostacyclin and throm boxane in human umbilical arteries was investigated by in vitro perfus ion. With perfusate concentrations ranging from 10(-7) to 10(-4) Ma de crease in the formation of both prostanoids was observed. The inhibito ry effect of phenazone on prostanoid formation was found to be equal t o that of indomethacin.