R. Thiergardt et al., CLADOSPIRONE BISEPOXIDE - DEFINITE STRUCTURE ASSIGNMENT INCLUDING ABSOLUTE-CONFIGURATION AND SELECTIVE CHEMICAL-TRANSFORMATIONS, Tetrahedron, 51(3), 1995, pp. 733-742
The definite structure of cladospirone bisepoxide 1 was determined as
1a by X-ray analysis. The absolute configuration could be deduced from
the X-ray crystallographic structure determination of its ring-opened
product 8. In order to define the structural features responsible for
various biological effects of this metabolite, the reactivity of the
epoxide and enone functional groups has been explored.