CLADOSPIRONE BISEPOXIDE - DEFINITE STRUCTURE ASSIGNMENT INCLUDING ABSOLUTE-CONFIGURATION AND SELECTIVE CHEMICAL-TRANSFORMATIONS

Citation
R. Thiergardt et al., CLADOSPIRONE BISEPOXIDE - DEFINITE STRUCTURE ASSIGNMENT INCLUDING ABSOLUTE-CONFIGURATION AND SELECTIVE CHEMICAL-TRANSFORMATIONS, Tetrahedron, 51(3), 1995, pp. 733-742
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404020
Volume
51
Issue
3
Year of publication
1995
Pages
733 - 742
Database
ISI
SICI code
0040-4020(1995)51:3<733:CB-DSA>2.0.ZU;2-Y
Abstract
The definite structure of cladospirone bisepoxide 1 was determined as 1a by X-ray analysis. The absolute configuration could be deduced from the X-ray crystallographic structure determination of its ring-opened product 8. In order to define the structural features responsible for various biological effects of this metabolite, the reactivity of the epoxide and enone functional groups has been explored.