CHARACTERISTICS AND SIGNIFICANCE OF THE AMORPHOUS STATE IN PHARMACEUTICAL SYSTEMS

The amorphous state is critical in determining the solid-state physica l and chemical properties of many pharmaceutical dosage forms, This re view describes the characteristics of the amorphous state and some of the most common methods that can be used to measure them. Examples of pharmaceutical situations where the presence of the amorphous state pl ays an important role are presented. The application of our current kn owledge to pharmaceutical formulation problems is illustrated, and som e strategies for working with amorphous character in pharmaceutical sy stems are provided.