DOES SUCRALFATE PREVENT SHORT-TERM NSAID-INDUCED DAMAGE TO THE GASTRODUODENAL MUCOSA

Citation
H. Gudjonsson et al., DOES SUCRALFATE PREVENT SHORT-TERM NSAID-INDUCED DAMAGE TO THE GASTRODUODENAL MUCOSA, Digestion, 55(6), 1994, pp. 395-398
Citations number
35
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
00122823
Volume
55
Issue
6
Year of publication
1994
Pages
395 - 398
Database
ISI
SICI code
0012-2823(1994)55:6<395:DSPSND>2.0.ZU;2-R
Abstract
The objective of the study was to assess whether sucralfate can preven t or diminish short-term nonsteroidal anti-inflammatory drug (NSAID)-i nduced damage in the stomach and duodenum. Sixteen healthy subjects we re randomly treated for 7 days with sucralfate 2 g b.d. or placebo in a double-blind cross-over manner. Naproxen 500 mg b.d, was given on da ys 3-7. Gastrointestinal endoscopy was performed before and after each treatment period. Mucosal damage was measured by counting erosions, s ubmucosal hemorrhages or ulcers on a fixed point scale of 0-4 for stom ach and duodenum separately. The mean posttreatment injury score in th e stomach was 2.13 +/- 1.51 and 2.0 +/- 0.97 for the placebo and sucra lfate periods, respectively (p = 0.72). The possibility of type II err or was 7%. In the duodenum, the injury score was 1.69 +/- 1.08 and 1.0 6 +/- 0.93 for the placebo and sucralfate periods, respectively (p = 0 .08). The possibility of type II error was 37%. Sucralfate has no effi cacy as a prophylactic agent against shortterm NSAID-induced gastroduo denal injury.