REGULATION OF SEX-HORMONE-BINDING GLOBULIN PRODUCTION BY ENDOGENOUS ESTROGENS IN-VITRO

Authors
LOUKOVAARA M CARSON M ADLERCREUTZ H
Citation
M. Loukovaara et al., REGULATION OF SEX-HORMONE-BINDING GLOBULIN PRODUCTION BY ENDOGENOUS ESTROGENS IN-VITRO, Biochemical and biophysical research communications, 206(3), 1995, pp. 895-901
Citations number
24
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
206
Issue
3
Year of publication
1995
Pages
895 - 901
Database
ISI
SICI code
0006-291X(1995)206:3<895:ROSGPB>2.0.ZU;2-B
Abstract
The effect of endogenous estrogens on sex-hormone-binding globulin (SH BG) production was studied in HepG2 cells. 17 beta-estradiol, estrone, and estrogens from both 2-and 16 alpha-hydroxylative pathways stimula ted SHBG production, but not in parallel with their binding affinities for the estrogen receptor. Thus, the underlying mechanism may be othe r than a pure interaction with the estrogen receptor. (C) 1995 Academi c Press, Inc.