Pulmonary embolism (PE) is largely undiagnosed because clinical suspic
ion is not raised in most instances, and thus, patients with PE go und
etected. In this pap er, we try to define the role of clinical assessm
ent (including chest radiograph, electrocardiogram, arterial blood gas
analysis) in making the diagnosis early, accurate, and at low cost, a
nd propose a flow chart to be used in clinical practice. All patients
with otherwise unexplained dyspnea or chest pain should be sent for pe
rfusion lung scintigraphy; accordingly, underdetection of PE and morta
lity of PE should be reduced. If, within I h after the clinical suspic
ion has been raised, the above-mentioned simple and noninvasive examin
ations are available, they may be employed to reduce the number of unn
ecessary procedures, without losing patients actually affected by PE.
Finally, when diagnostic tools are not promptly available, noninvasive
techniques may be employed to identify patients with the highest prob
ability of PE where to start with heparin coverage while waiting for d
efinitive diagnosis.