Sore throat is a common presenting complaint. Although patients often
are concerned that they may have group A beta-hemolytic streptococcal
(GABHS) pharyngitis, most sore throats are not caused by this infectio
n. A number of illnesses and conditions present as sore throat. After
life-threatening conditions are excluded, efforts to identify and trea
t patients with GABHS pharyngitis are appropriate. Efforts should incl
ude a directed history and physical examination, looking for exudative
pharyngitis with fever, adenopathy and lack of cough or other respira
tory symptoms. These findings predict a positive GABHS culture rate of
50 percent or more. The rapid Streptococcus test has a high positive
predictive value, but it has a lower sensitivity rate. Treatment strat
egies for patients with sore throat are based on epidemiologic factors
, signs and symptoms, and results of laboratory tests.