ELECTRONICALLY MODULATED BIOLOGICAL FUNCTIONS OF MOLECULAR INTERFACEDENZYMES AND LIVING CELLS

Conducting polymer molecular interfaces have been implemented to modul ate biological functions of fructose dehydrogenase, pyruvate oxidase a nd Saccharomyces cerevisiae at the electrode surface by adjustment of electrode potential. The enzyme activity of the polypyrrole-interfaced fructose dehydrogenase was electronically modulated by means of elect ron transfer between the enzyme and the electrode surface. The enzyme activity of polypyrrole-interfaced pyruvate oxidase was modulated by a n electronically driven change of substrate concentration. The gene ex pression in polypyrrole-interfaced Saccharomyces cerevisiae was electr onically induced by a change in the phosphate concentration.