T. Brzostek et al., DETERMINANTS OF LEFT-VENTRICULAR FUNCTION 2 WEEKS AND ONE-YEAR AFTER AN ACUTE MYOCARDIAL-INFARCTION, Angiology, 46(1), 1995, pp. 27-36
Citations number
42
Categorie Soggetti
Medicine, General & Internal","Cardiac & Cardiovascular System","Peripheal Vascular Diseas
This study examines possible covariates of left ventricular function t
wo weeks and sixteen months after an acute infarction. It was performe
d in a group of 312 patients randomized double blindly to recombinant
tissue plasminogen activator (rt-PA) (n=156) or placebo treatment and
followed thereafter for at least one year. Two weeks after the infarct
ion, enzymatic infarct size, infarct-related vessel, and number of dis
eased coronary arteries were significant determinants of the infarct-r
elated regional wall motion (centerline method) (R(2)=0.25 to 0.60, P=
0.0001). Enzymatic infarct size, regional wall motion of both infarct-
related and remote areas, reinfarction, and treatment allocation were
significant independent correlates of ejection fraction (R(2)=0.76), e
nd-diastolic volume (R(2)=0.20), and end-systolic volume (R(2)=0.69, P
< 0.0001). Infarct-related coronary artery and predischarge end-systo
lic volume were significant independent covariates of ejection fractio
n at rest (R(2)=0.473 after sixteen months. Age, enzymatic infarct siz
e, and predischarge end-diastolic volume were independent determinants
of the maximal (R(2)=0.49, P < 0.0001) and peak exercise ejection fra
ction (R(2)=0.49, P < 0.0001).