This paper aims to assess the reliability of Local Research Ethical Co
mmittees (LREC), using a genuine research proposal which was sent to s
ix LRECs. The main outcome criteria were modifications demanded by com
mittees and the degree of agreement between them. All but one of the c
ommittees demanded some change in the proposal. None of the committees
asked for the same changes. Our conclusion is that LRECs are highly v
ariable.