TRANSFECTION OF SENDAI-VIRUS F-GENE CDNA WITH MUTATIONS AT ITS CLEAVAGE SITE AND HN GENE CDNA INTO COS CELLS INDUCES CELL-FUSION

Authors
TAIRA H SATO T SEGAWA H CHIBA M KATSUMATA T IWASAKI K
Citation
H. Taira et al., TRANSFECTION OF SENDAI-VIRUS F-GENE CDNA WITH MUTATIONS AT ITS CLEAVAGE SITE AND HN GENE CDNA INTO COS CELLS INDUCES CELL-FUSION, Archives of virology, 140(1), 1995, pp. 187-194
Citations number
38
Categorie Soggetti
Virology
Journal title
Archives of virology → ACNP
ISSN journal
03048608
Volume
140
Issue
1
Year of publication
1995
Pages
187 - 194
Database
ISI
SICI code
0304-8608(1995)140:1<187:TOSFCW>2.0.ZU;2-8
Abstract
In contrast to the wild type Sendai virus fusion protein (F), a mutate d F to possess a cleavage site similar to that of virulent Newcastle d isease virus F, could be cleaved by proteases present in COS cells. Wh en mutated F and hemagglutinin-neuraminidase (HN) were coexpressed at the cell surface, syncytium formation was observed.