J. Castanedaacosta et al., EXTRACTION OF BIOACTIVE SESQUITERPENE LACTONES FROM MAGNOLIA-GRANDIFLORA USING SUPERCRITICAL CARBON-DIOXIDE AND NEAR-CRITICAL PROPANE, Journal of agricultural and food chemistry, 43(1), 1995, pp. 63-68
The bioactive sesquiterpene lactones parthenolide and costunolide, as
well as the tricyclic sesquiterpene cyclocolorenone, were extracted fr
om the leaves of Magnolia grandiflora by supercritical extraction with
carbon dioxide and by near-critical extraction with propane. Partheno
lide, costunolide, and cyclocolorenone in the extracts were identified
by H-1 NMR and quantified by HPLC. Results indicate that supercritica
l carbon dioxide selectively removed parthenolide, costunolide, and cy
clocolorenone when compared to standard liquid dichloromethane or near
-critical propane extraction. HPLC traces show that the carbon dioxide
extract is virtually clean of any chlorophyll or fatty material peaks
which hinder isolation of these chemicals.