Certain human talents, such as musical ability, have been associated w
ith left-right differences in brain structure and function. In vivo ma
gnetic resonance morphometry of the brain in musicians was used to mea
sure the anatomical asymmetry of the planum temporale, a brain area co
ntaining auditory association cortex and previously shown to be a mark
er of structural and functional asymmetry. Musicians with perfect pitc
h revealed stronger leftward planum temporale asymmetry than nonmusici
ans or musicians without perfect pitch. The results indicate that outs
tanding musical ability is associated with increased leftward asymmetr
y of cortex subserving music-related functions.