Ma. Malone et al., RIGHT-HEMISPHERE DYSFUNCTION AND METHYLPHENIDATE EFFECTS IN CHILDREN WITH ATTENTION-DEFICIT HYPERACTIVITY DISORDER, Journal of child and adolescent psychopharmacology, 4(4), 1994, pp. 245-253
The purposes of this study were to investigate the previously reported
right hemisphere dysfunction in children with attention-deficit/hyper
activity disorder (ADHD) and to test for stimulant medication treatmen
t effects. Seventeen children with ADHD were assessed on a letter canc
ellation task on placebo and on methylphenidate. On placebo, ADHD chil
dren detected fewer targets on the left side of the page than on the r
ight side of the page, thus demonstrating evidence of partial left vis
ual field neglect and, by implication, right hemisphere dysfunction. T
he ADHD children with comorbid learning disabilities appeared to large
ly account for this result. On medication, there was no longer evidenc
e of the partial left visual field neglect or right hemisphere dysfunc
tion. Thus, it appears that ADHD, particularly with comorbid learning
disabilities, may involve right hemisphere dysfunction which is partia
lly corrected with methylphenidate.