DOES THE TYPE OF BCR ABL JUNCTION PREDICT THE SURVIVAL OF PATIENTS WITH PH(1)-POSITIVE CHRONIC MYELOID-LEUKEMIA/

Authors
ZACCARIA A MARTINELLI G TESTONI N ZUFFA E FARABEGOLI P RUSSO D GUERRASIO A TURA S
Citation
A. Zaccaria et al., DOES THE TYPE OF BCR ABL JUNCTION PREDICT THE SURVIVAL OF PATIENTS WITH PH(1)-POSITIVE CHRONIC MYELOID-LEUKEMIA/, Leukemia & lymphoma, 16(3-4), 1995, pp. 231-236
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Leukemia & lymphoma → ACNP
ISSN journal
10428194
Volume
16
Issue
3-4
Year of publication
1995
Pages
231 - 236
Database
ISI
SICI code
1042-8194(1995)16:3-4<231:DTTOBA>2.0.ZU;2-C
Abstract
The prognostic value of the site of DNA rearrangement within the M-BCR on chromosome 22 or of the type of transcript has been debated in the last years. The majority of the studies do not support the hypothesis of a predictive value of such molecular parameters. Results coming fr om a multicentric, prospective trial, based on alpha-IFN therapy, seem to indicate a better karyotypic response in 3' rearranged patients. T he possibility of evoking a cytotoxic immune response directed towards peptides originating from each of the different BCR/ABL junctions con stitute an important challenge for the future.