THE GENE CODING FOR THE B-CELL SURFACE PROTEIN CD19 IS LOCALIZED ON HUMAN-CHROMOSOME 16P11

Authors
STAPLETON P KOZMIK Z WEITH A BUSSLINGER M
Citation
P. Stapleton et al., THE GENE CODING FOR THE B-CELL SURFACE PROTEIN CD19 IS LOCALIZED ON HUMAN-CHROMOSOME 16P11, Human genetics, 95(2), 1995, pp. 223-225
Citations number
21
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
95
Issue
2
Year of publication
1995
Pages
223 - 225
Database
ISI
SICI code
0340-6717(1995)95:2<223:TGCFTB>2.0.ZU;2-K
Abstract
The CD19 gene codes for one of the earliest markers of the human B cel l lineage and is a target for the B lymphoid-specific transcription fa ctor BSAP (Pax-5). The transmembrane protein CD19 has been implicated in controlling proliferation of mature B lymphocytes by modulating sig nal transduction through the antigen receptor. In this study, we have employed Southern blot and fluorescence in situ hybridization analyses to localize the CD19 gene to human chromosome 16p11.