Jc. Mcnaughton et al., PHYLOGENETIC-RELATIONSHIPS AMONG TRANSPOSON-LIKE ELEMENTS IN HUMAN AND PRIMATE DNA, Journal of molecular evolution, 40(2), 1995, pp. 127-135
A THE-1 sequence in intron 7 of the human dystrophin gene has been fou
nd to represent a new subfamily of THE-1 elements. The sequence is clo
sely related to the MstII family of repetitive sequences and is more l
ike single-copy sequences found in the galago genome than any other TH
E-1 sequence previously reported. This new THE-1 sequence has been com
pared with two other complete THE-1 sequences and three related long-t
erminal repeat elements that we have previously found in intron 7 of t
he dystrophin gene, and with members of the same family from elsewhere
in the primate genome. Parsimony and deletion analysis show that the
cluster of THE-1 sequences in intron 7 of the dystrophin gene has aris
en from at least three individual insertion events, rather than from t
he insertion and duplication of a single progenitor sequence.