This study was designed to evaluate the gasometric and functional resp
iratory responses in chronic bronchitic patients with chronic respirat
ory insufficiency (CRI) under ambulatory oxygen therapy (AOT) with alm
itrine bismesylate (AB). It was a double-blind, placebo-controlled, ra
ndomized, prospective study which lasted three months and with a dosag
e regime of 50-100 mg/day of AB. Fiftyfour patients completed the stud
y (28 in AB and 24 in the placebo (P) groups, respectively). All patie
nts were males, with a mean age or 65+/-6.1 years. In the study of pul
monary function only airway resistance (Raw) was changed, with a signi
ficant decrease at the third month in the AB group compared with the P
group (0.83+/-0.31 vs. 1.07+/-0.46 kpa/L.S), with a p value of 0.05 (
mean+/-SD) and PaO2 which improved from 8.15+/-0.88 to 8.81+/-2.3 kpa
(61.17+/-6.6 to 66.10+/-10 mmHg), with a p value of 0.05. AB therapy w
as well tolerated.