PREVENTION OF THE ISCHEMIC-INJURY IN HEPA TOCELLULAR TRANSPLANTATION IN THE RAT

The aim of this study was to evaluate the efficacy of certain antioxid ant and/or hepatotrophic drugs on the sensivity to ischemia of hepatoc ytes implanted into the spleen. Twenty four hours after hepatocellular transplantation, animals were submitted to 15 minutes of normotermic ischemia followed by 70% hepatectomy. Hepatocytic function was assesse d 24 h later by measuring the intensity of the regenerative response, both in the liver and in the spleen. All drugs increased the percentag e of regenerating hepatocytes, but only allopurinol and cyclosporine a chieved significance. However none of the drugs were useful for hepato cytes implanted in the spleen, allopurinol having a deleterious effect .