TRANSIENT NEONATAL DIABETES AND LATER ONSET DIABETES - A CASE OF INHERITED INSULIN-RESISTANCE

Authors
SHIELD JPH BAUM JD
Citation
Jph. Shield et Jd. Baum, TRANSIENT NEONATAL DIABETES AND LATER ONSET DIABETES - A CASE OF INHERITED INSULIN-RESISTANCE, Archives of Disease in Childhood, 72(1), 1995, pp. 56-57
Citations number
6
Categorie Soggetti
Pediatrics
Journal title
Archives of Disease in Childhood → ACNP
ISSN journal
00039888
Volume
72
Issue
1
Year of publication
1995
Pages
56 - 57
Database
ISI
SICI code
0003-9888(1995)72:1<56:TNDALO>2.0.ZU;2-D
Abstract
A 13 year old girl who had had transient neonatal diabetes developed p ermanent diabetes. She had raised fasting insulin concentrations sugge stive of insulin resistance with a suboptimal insulin response to gluc ose loading. Both her mother and sister had profound insulin resistanc e; neither had clinical diabetes. This is the first time inherited ins ulin resistance has been implicated in the pathogenesis of permanent d iabetes developing after transient neonatal diabetes.