HEREDITARY MULTIINFARCT DEMENTIA UNLINKED TO CHROMOSOME 19Q12 IN A LARGE SCOTTISH PEDIGREE - EVIDENCE OF PROBABLE LOCUS HETEROGENEITY

Hereditary multi-infarct dementia is a rare autosomal dominant disorde r that predominantly affects the cerebral white matter. A locus was re cently mapped in French pedigrees to chromosome 19q12. We have examine d a large Scottish pedigree with neuropathologically confirmed heredit ary multi-infarct dementia using polymorphic DNA markers spanning the 19q12 region and found no evidence of linkage. This suggests that, as in familial Alzheimer's disease, there is more than one locus.