The emergence of a relational perspective in psychoanalytic thought su
ggests the need for new paradigms of symptom formation. In addition, b
iopsychosocial data on the etiology of a number of specific disorders
have been accumulating. Self psychology is proposed as a relational mo
del of psychopathology that can be incorporated into a biopsychosocial
paradigm of symptom formation for Axis I disorders. Four specific pat
hways to symptom formation are outlined. The first consists of a self-
state of impending fragmentation that is then warded off through invol
vement with a substance or activity, as in addictive disorders. The se
cond denotes a state of fragmentation without a behavioral means of se
lf-restitution other than avoidance, seen in anxiety disorders. The th
ird involves the use of a symptom as a compromise formation among conf
licting impulses as a result of psychological trauma, as in dissociati
ve and somatoform disorders. In the final pathway that I outline, symp
toms such as depressive states and work inhibitions result from an int
ernalized conflict between maintaining needed relationships and pursui
ng self-differentiation. Both internal conflict and developmental defi
cit are central in the genesis of symptomatic disorders.