HEMODYNAMIC-EFFECTS OF INTRAVENOUS FAMOTIDINE IN PATIENTS UNDERGOING CARDIAC-SURGERY

Study Objective. To determine the hemodynamic effects of famotidine in patients undergoing cardiac surgery. Design. A prospective, randomize d, double-blinded, placebo-controlled study. Setting. A large universi ty teaching hospital. Patients. Twenty-one patients undergoing electiv e cardiac surgery with cardiopulmonary bypass. Interventions. The pati ents received a rapid intravenous bolus injection of famotidine 20 mg or saline placebo after anesthesia induction. A second dose was given 12 hours after surgery in the intensive care unit. Measurements and Ma in Results. Serial hemodynamic measurements (heart rate, arterial bloo d pressure, cardiac index, pulmonary arterial pressure, central venous pressure, systemic vascular resistance) were obtained after each famo tidine or placebo dose and analyzed by ANOVA. The values were not alte red (p>0.05) after intraoperative or postoperative famotidine or place bo administration. Conclusions. Rapid intravenous bolus administration of famotidine does not alter patient hemodynamics after anesthesia in duction or in the intensive care unit after cardiac surgery.