IMMUNOLOGICALLY IGNORANT AUTOREACTIVE T-CELLS, EPITOPE SPREADING AND REPERTOIRE LIMITATION

Authors
ELSON CJ BARKER RN THOMPSON SJ WILLIAMS NA
Citation
Cj. Elson et al., IMMUNOLOGICALLY IGNORANT AUTOREACTIVE T-CELLS, EPITOPE SPREADING AND REPERTOIRE LIMITATION, Immunology today, 16(2), 1995, pp. 71-76
Citations number
40
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
16
Issue
2
Year of publication
1995
Pages
71 - 76
Database
ISI
SICI code
0167-5699(1995)16:2<71:IIATES>2.0.ZU;2-R
Abstract
The factors that may cause antigen-presenting cells to alter the patte rn of protein Processing and presentation to autoreactive T cells, and thereby stimulate autoimmune disease, are currently under debate. In this article, Chris Elson and colleagues suggest that cytokines associ ated with T helper 1 (Th1) cells alter the processing of proteins and that this effect can be counteracted by Th2-associated cytokines.