A SIGNALING PATHWAY GOVERNING EARLY THYMOCYTE MATURATION

Authors
ANDERSON SJ PERLMUTTER RM
Citation
Sj. Anderson et Rm. Perlmutter, A SIGNALING PATHWAY GOVERNING EARLY THYMOCYTE MATURATION, Immunology today, 16(2), 1995, pp. 99-105
Citations number
60
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
16
Issue
2
Year of publication
1995
Pages
99 - 105
Database
ISI
SICI code
0167-5699(1995)16:2<99:ASPGET>2.0.ZU;2-C
Abstract
Recent evidence supports the view that p56(lck), a non-receptor protei n tyrosine Kinase, serves as the signaling element that 'senses' synth esis of a functional T-cell receptor beta chain, thereby promoting thy mocyte maturation. Here, Steven Anderson and Roger Perlmutter review c urrent data, and outline the features of this developmental program.