A TECHNIQUE FOR STUDYING THE FUNCTION OF AN ISOLATED, PERFUSED AND VENTILATED LUNG IN A RAT MODEL

Authors
HOPKINSON DN ODOM NJ ELOAKLEY RM AU J HOOPER TL
Citation
Dn. Hopkinson et al., A TECHNIQUE FOR STUDYING THE FUNCTION OF AN ISOLATED, PERFUSED AND VENTILATED LUNG IN A RAT MODEL, Laboratory animals, 29(1), 1995, pp. 96-101
Citations number
10
Categorie Soggetti
Veterinary Sciences
Journal title
Laboratory animals → ACNP
ISSN journal
00236772
Volume
29
Issue
1
Year of publication
1995
Pages
96 - 101
Database
ISI
SICI code
0023-6772(1995)29:1<96:ATFSTF>2.0.ZU;2-5
Abstract
We describe a technique which allows perfusion of an isolated, ventila ted rat lung with an extracorporeal veno-venous circuit from a support animal. This model provides stable and reliable function of the isola ted lung for up to 3 h, thus overcoming some of the disadvantages of p revious models. It may prove a potentially useful model for assessing ischaemic lung injury.