Human unconventional viruses infections are scarcely found with a worl
dwide occurrence below 1/million inhabitants. The disease would be ind
uced by an interaction between the patient's genetic characteristics a
nd environmental factors. No link has been found between the occurrenc
e of the disease in man and the presence of the animal form of the dis
ease, i.e. scrapie. The professional risk has been pointed out for peo
ple working with animals or in the medical sector. Most iatrogenic cas
es are subsequent to a growth hormone treatment. The other cases are a
ssociated with different medical and surgical acts. But the transmissi
on by blood transfusion remains questionable and must be clearly demon
strated. A European multidisciplinary study was launched in 1992 in or
der to set up an epidemiological surveillance network and to study ris
k factors in the best conditions.