UNSYMMETRICAL BOROLE COMPLEXES AS BIOCIDES - SYNTHETIC, STRUCTURAL AND BIOLOGICAL ASPECTS

Triisopropoxyborane on treatment with catechol in equimolar ratio in e xcess of benzene affords the formation of 2-isopropoxybenzo-1,3-dioxa- 2-borole [OC6H4OB(OPri)]. The interaction of [OC6H4OB(OPri)] with benz othiazolines, prepared by the condensation of [1-(2-thienyl)ethanone], [1-(2-pyridinyl)ethanonel, [1-(2-furanyl)ethanone], and -1-(2-naphthe nyl)ethanone] with 2-mercaptoaniline, yields complexes that have B-O, B-S, and B<--N bonds. The unsymmetrical borole complexes were subjecte d to microestimations and spectral analyses comprised of UV, IR, proto n-1, boron-11, and carbon-13 nuclear magnetic resonance studies. The s pectral studies point to a tetracoordinated environment around boron b ecause the stereochemically active lone pair is also included in the c oordination sphere. X-ray powder diffraction of a representative compl ex also has been carried out. In the quest for better fungicides and b actericides, studies were conducted to assess the growth-inhibiting po tential of the synthesized complexes along with the ligands against va rious fungal and bacterial strains. The studies demonstrate that the c oncentrations reach levels that are sufficient to inhibit and kill the pathogens. Furthermore, the results achieved from biological activity also have been compared with the conventional fungicide, Bavistin, an d conventional bactericide, Streptomycin.