MOLECULAR-GENETICS OF THE S-A GENE

1. We have recently identified a candidate gene for rat genetic hypert ension, termed S-A, by identifying an mRNA species that shows markedly higher expression in the kidneys of spontaneously hypertensive rats ( SHR) than in those of Wistar-Kyoto rats (WKY). 2. Subsequent genetic c o-segregation analyses by ourselves and others indicated that the S-A gene locus did indeed influence blood pressure. Moreover, in a prelimi nary association study, we found an association of a polymorphism of t he human S-A gene with essential hypertension. 3. Further studies to i dentify functions of the S-A gene products are required before reachin g a definite conclusion.