CELLULOSE-ACETATE TRIMELLITATE MICROSPHERES CONTAINING NSAIDS

Indomethacin and ketoprofen (non-steroidal anti-inflammatory drugs) we re incapsulated with cellulose acetate trimellitate, enteric polymer, using a spray drying technique. Organic solutions of polymer and drug were prepared in different weight ratios and sprayed, achieving drug l oaded microspheres. The obtained spray dried microparticles were chara cterized in terms of yield of production, shape, size, morphological c haracteristics and drug content. The in vitro drug release tests, carr ied out using a pH change method with a flow-through cell apparatus, s how a typical delayed drug release due to the pH-dependent solubility of the polymer.