A COMPARISON OF FREE-FLOWING, SEGREGATING AND NON-FREE-FLOWING, COHESIVE MIXING SYSTEMS IN ASSESSING THE PERFORMANCE OF A MODIFIED V-SHAPEDSOLIDS MIXER
Rk. Chang et al., A COMPARISON OF FREE-FLOWING, SEGREGATING AND NON-FREE-FLOWING, COHESIVE MIXING SYSTEMS IN ASSESSING THE PERFORMANCE OF A MODIFIED V-SHAPEDSOLIDS MIXER, Drug development and industrial pharmacy, 21(3), 1995, pp. 361-368
The performance of a modified V-shaped solids mixer, i.e., uneven leg
or offset angle, has been reassessed by using a binary cohesive mixtur
e, made up of 1% sodium salicylate and 99% microcrystalline cellulose,
as the mixing system. The performance of the mixer was defined in ter
ms of relative standard deviation from the measured mean. The results
generated from the present study were compared with the previously pub
lished data generated by using a free-flow mixing system. It appears i
n the present study that the free-flowing, segregating materials may b
e;used as a mixing model to predict the trend of the performance of a
modified V-shaped blender for the non-free-flowing, cohesive materials
. However, in the equilibrium state, the non-free-flowing, cohesive mi
xture has much better quality of the mix than that of the free-flowing
, segregating system in terms of the scale and intensity of segregatio
n.