Ly. Lim et Lsc. Wan, COMBINED EFFECTS OF HEAT-TREATMENT AND PLASTICIZERS ON POLYVINYL-ALCOHOL FILMS, Drug development and industrial pharmacy, 21(3), 1995, pp. 369-373
The effects of heat treatment on PVA films containing water soluble pl
asticizers were investigated. Propylene glycol, glycerol and polyethyl
ene glycol were used as plasticizers. There was synergism between heat
treatment and the presence of plasticizers in enhancing the water res
istance of PVA films. In the absence of heat treatment, however, the p
lasticizers increased the aqueous solubility of PVA films. The plastic
ized films further showed a lower permeability to propranolol HCl comp
ared to the unplasticized films following heat treatment.