COMBINED EFFECTS OF HEAT-TREATMENT AND PLASTICIZERS ON POLYVINYL-ALCOHOL FILMS

Authors
Citation
Ly. Lim et Lsc. Wan, COMBINED EFFECTS OF HEAT-TREATMENT AND PLASTICIZERS ON POLYVINYL-ALCOHOL FILMS, Drug development and industrial pharmacy, 21(3), 1995, pp. 369-373
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
03639045
Volume
21
Issue
3
Year of publication
1995
Pages
369 - 373
Database
ISI
SICI code
0363-9045(1995)21:3<369:CEOHAP>2.0.ZU;2-O
Abstract
The effects of heat treatment on PVA films containing water soluble pl asticizers were investigated. Propylene glycol, glycerol and polyethyl ene glycol were used as plasticizers. There was synergism between heat treatment and the presence of plasticizers in enhancing the water res istance of PVA films. In the absence of heat treatment, however, the p lasticizers increased the aqueous solubility of PVA films. The plastic ized films further showed a lower permeability to propranolol HCl comp ared to the unplasticized films following heat treatment.