The multi-allelic self-incompatibility polymorphisms in angiosperms ha
ve long interested geneticists and population geneticists, but the lim
its of classical genetic resolution were reached many years ago. In re
cent years, new progress has been made by molecular genetic approaches
. Intriguing similarities to and differences from the fungal systems a
re emerging. The polymorphism at these loci is now known to be even mo
re baroque than appeared from classical genetic studies. Alleles diffe
r so much at the level of both the DNA and protein sequence that they
would be difficult to recognise as products of the same locus, were it
not for the presence of certain conserved regions. Despite the succes
ses of the recent work, the locus responsible for the specificity of t
he incompatibility reaction in pollen, and the mechanism of self-incom
patibility, remain elusive.