A 50-HZ SINUSOIDAL MAGNETIC-FIELD INDUCES CHANGES IN THE MEMBRANE ELECTRICAL-PROPERTIES OF K562 LEUKEMIC-CELLS

The cell membrane appears to be one of the major targets of extremely low frequency (ELF) magnetic fields. To determine whether the membrane electrical properties of K562 leukaemic cells can be affected by ELF fields, these cells were exposed to a sinusoidal 50 Hz 2.5 mT magnetic field for 48 h. It should be recalled that the field intensity used i s three or four orders of magnitude greater than the values found in h omes and in many workplaces. Analyses of dielectric relaxation measure ments in the r.f. range demonstrate that both the membrane electrical conductivity and permittivity of K562 cells decrease considerably afte r exposure of these cells to ELF fields, whereas the conductivity of t he cytosol does not vary. Since both membrane conductivity (a measure of the dynamic ionic movement across cell membranes) and membrane perm ittivity (an indicator of the ionic charges present on cell membranes) vary, these data seem to suggest that exposure of K562 leukaemic cell s to ELF fields affects both static and dynamic properties of these ce lls.