STUDIES OF THE SENSORY-MOTOR RESPONSE IN RATS WITH INNATE HIGH-LEVEL OF ANXIETY

Citation
Na. Krupina et al., STUDIES OF THE SENSORY-MOTOR RESPONSE IN RATS WITH INNATE HIGH-LEVEL OF ANXIETY, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 44(6), 1994, pp. 1097-1105
Citations number
24
Categorie Soggetti
Physiology,Neurosciences
ISSN journal
00444677
Volume
44
Issue
6
Year of publication
1994
Pages
1097 - 1105
Database
ISI
SICI code
0044-4677(1994)44:6<1097:SOTSRI>2.0.ZU;2-X
Abstract
Sensory-motor response was measured by acoustic startle reflex in Wist ar male rats with innate high and low levels of anxiety. The levels of anxiety were determined using a complex multiparameter method for eva luating anxiety-phobic states in rats by a ranged scale. Amplitude and prepulse inhibition of the acoustic startle response were increased, but latency of the startle reflex was decreased in rats with innate hi gh level of anxiety as compared with those with innate low level. In r ats with innate high level of anxiety injection of subconvulsive doses of pentylenetetrazol (10 and 15 mg/kg i. p.) resulted in an increase of the amplitude of the acoustic startle response and, additionally (u nder the dose 10 mg/kg) in a decrease of its latency. Facilitation of acoustic startle in rats with innate high level of anxiety is suggeste d to reflect either a deficit of inhibitory, or intensification of exc itatory modulating influences on signal transmission in nerve circuit of acoustic startle. Studies of the sensory-motor response by acoustic startle in rats with innate high level of anxiety are believed to be useful for elucidating basic mechanisms of anxiety and phobia.