NEUROCHEMICAL PROFILE OF THE CENTRAL NUCL EUS OF THE AMYGDALAR COMPLEX AND ANXIOLYTIC EFFECT OF TRANQUILIZERS IN DIFFERENT ANXIETY TESTS INRATS

Chemical stimulation of the central nucleus of the amigdalar complex w as carried out in rats during performance of tests of avoidance of ''l ighted square'' and ''threatening situation''. Microinjections of mono amines, GABA, glutamate, some of their receptor agonists and antagonis ts revealed neurochemical heterogeniity of the structure and functiona l ambiguity of neurotransmitter systems in genesis of anxiety of diffe rent aversive modes. Chlordiazepoxid, phenibut, indoter, campiron, cam pironin decrease anxiety in the tests of avoidance of ''lighted square '' and ''threatening situation'', their effects being similar to those of dopamine, GABA, or serotonin. A conclusion is made that distinctio ns in spectra of anxiosedative and anxioselective drugs under study ma y be caused by unequal contribution of monoamine and aminoacid transmi tter mechanisms of the central region of the amigdalar complex in gene sis of heteromodal aversive anxiety.